18 Apr 2017

UTERINE MICROBIOTA PLAY A KEY ROLE IN IMPLANTATION AND PREGNANCY SUCCESS IN IVF

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Endometrial microbiota (bacteria in the uterine cavity) play an important role in determining whether women are able to get pregnant via in IVF according to a new study published in the American Journal of Obstetrics and Gynecology.

Endometrial fluid and vaginal fluid samples were collected at pre-receptive and receptive phases within the same cycle from 22 fertile women; also from 35 infertile patients undergoing IVF

When paired endometrial fluid and vaginal fluid samples from the same patients were examined, different bacterial communities were detected between the two sites in some women.

The microbiota in the endometrial fluid of the fertile woman was classified as Lactobacillus-dominated or non-Lactobacillus-dominated microbiota.

On the other hand, women with a non-Lactobacillus-dominated microbiota and a receptive endometrium had a significantly lower rate of implantation, pregnancy, and live birth than patients with a Lactobacillus-dominated microbiota.

This work shows for the first time, that colonization of the uterine cavity with some bacteria (non Lactobacillus-dominated) affects the success of in vitro fertilization, pregnancy rates, and live births.

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